Whether you need to lose 10 pounds or 100, attaining your weight loss goals is one of the most challenging undertakings of modern times. There is so much conflicting information about weight loss, some of it based on solid science, some of it observational, and much of it simply aimed at making money at your expense, without providing effective results.
One thing we do know for a fact: fat is synthesized in the liver and metabolized in cellular mitochondria, and both mitochondrial and liver function are heavily dependent on a coenzyme called nicotinamide adenine dinucleotide (NAD).
How Excess Body Weight Impacts Your Health
Despite the body positivity movement that recognizes the injustices of stereotyping individuals based on body weight, shape and size, carrying excess body weight can take a hefty toll on your overall health.
According to an article published by the Harvard School of Public Health, being overweight can impact your health in multiple ways:
- Increased risk of Type II diabetes
- Increased risk of heart disease
- Increased risk of life-threatening cancers
- Compromised reproductive health
- Increased risk of cognitive dysfunction
- Increased risk of musculoskeletal disorders
- Increased depression
- Lower overall quality of life
- Reduced immune function
- Greater risk of respiratory disease, including COVID
- Increased risk of premature death
With so much at stake, especially considering the role of obesity in hospitalization and death from COVID, it makes sense to find a weight loss strategy that helps you improve your health over the long run.
How NAD Affects Fat Metabolism
NAD is an essential coenzyme found in every cell in the human body. As you age beyond your reproductive prime, NAD levels tend to fall off, especially if you are not physically active and eat a nutrient-poor diet. In addition, consumption of sugars and refined carbohydrates, excessive alcohol consumption, excessive use of NSAIDs, and regular daily doses of certain medications can all depress NAD levels in the liver, interfering with your ability to metabolize fat.
In your muscle cells, tiny organelles called mitochondria work around the clock to transform fats and carbohydrates into ATP, the energy molecule. NAD plays a key role in the citric acid cycle (aka Krebs cycle) responsible for manufacturing ATP. However, the size and number of available mitochondria and their capacity to convert fat to energy is largely determined by your physical activity level. The more you use your muscles, the greater the size and number of mitochondria, and the better your ability to burn fat for fuel.
People who are physically active have more and larger mitochondria, and more NAD to facilitate fat metabolism in the cells. But even physically active people experience reduced levels of NAD as they age, limiting their ability to metabolize fat. Supplementing with nicotinamide riboside (NR) for weight loss can help accelerate fat metabolism to help you reach your goals.
A recent placebo-controlled study (Fluharty et al., 2020) of obese male and female subjects found that, when given one gram of NR per day for 6 weeks, they reduced their total fat mass by an average of 1.34 percent, without exercise. Researchers concluded that adding an exercise component and other lifestyle modifications to an NR supplementation protocol would likely produce steady weight loss over time.
How to Increase NAD Levels
There are multiple things you can do to boost your body’s natural production of NAD and promote weight loss.
- Increase your physical activity level with both cardio and resistance training
- Eat a protein-rich diet, low in sugar, alcohol and refined carbohydrates
- Fast intermittently to cleanse your liver and boost metabolism
- Avoid sunburn
- Drink one ounce of water daily for every 2 pounds of body weight
- Supplement with nicotinamide riboside (NR)
Successful weight loss depends on a combination of strategies to optimize fat metabolism. When you implement a multi-pronged approach and stick to it on a daily basis, you will begin to see a dramatic difference in how you look and feel.
NAD IV Therapy for Weight Loss
Your body needs ample amounts of nicotinamide riboside (NR) to manufacture an effective amount of NAD for weight loss. While you can purchase oral supplements, they vary in potency and quality, and much of their potency can be lost in the digestive process.
NAD IV therapy is an easy and effective way to deliver high doses of NR to your cells, to increase NAD levels without relying on digestion and absorption. During your NAD IV session, a potent NR solution is infused directly into your bloodstream, for rapid transport to depleted cells. Regular NAD IV therapy sessions can give your liver and mitochondria the nutrients they need to better metabolize fat and promote healthy weight loss.
NAD IV Therapy in NYC
If you are ready to get serious about losing weight and regaining your health, Advanced Cryo NYC offers the solutions and support you need to succeed. In addition to NAD IV therapy, we offer a wide range of IV vitamin cocktails and cryotherapy options to keep you looking and feeling your best. Your health is your most valuable asset. Make the most of it by living your best life with help from Advanced Cryo NYC. Contact us today!
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Fluharty, Noah T., and Charles Brenner. “Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it’s time to test with exercise.” (2020): 243-244.
Parker, Richard, et al. “The NAD metabolome is functionally depressed in patients undergoing liver transplantation for alcohol-related liver disease.” bioRxiv (2020).