Time for a Reset with NAD+ IV Therapy!
There is no denying that obesity has become a major health problem in the United States and other Western countries, dramatically impacting quality of life for millions, and costing billions in the treatment of associated metabolic issues. Both the causes and solutions of obesity are multifaceted, but one thing is certain – the issue is more than a calories in/calories out equation.
Learn about the causes of weight gain, the role of metabolism in weight management, and how NAD+ therapy can help put you on the path toward attaining your ideal body weight.
Unwanted Weight Gain is More than Cosmetic
In recent years, much effort has been made to normalize obesity, spawning the “Body Positive” movement and shaming critics who warn about health risks. But the “fat is beautiful” mantra rings hollow. Obesity is more than a cosmetic issue – it is a critical metabolic issue that comes with a myriad of comorbidities and disabilities that place a burden on society at large.
Health issues related to obesity include:
- Cardiovascular diseases like hypertension, atherosclerosis, heart failure, and more.
- Metabolic disorders like insulin resistance, diabetes, chronic inflammation, and low testosterone. Up to 90 percent of Type 2 diabetes cases are directly related to obesity.
- Cancers affecting vital organs such as breast, ovarian, pancreatic, liver, prostate and other cancers, with at least 13 showing a significant link to obesity.
- Gallstones and non-alcoholic fatty liver disease.
- Respiratory conditions like sleep apnea and asthma.
- Musculoskeletal disorders like chronic low back pain, gout, and osteoarthritis.
- Reproductive dysfunction and childbirth-related complications.
- Chronic kidney disease.
- Reduced mobility and diminished quality of life.
What is Causing the Obesity Epidemic?
Young people born in the late 1990s and early 2000s are likely unaware of how human bodies have ballooned in the 21st Century, but we only need to look at movies and TV shows from the ’70s and ’80s to recognize that Americans have been super-sized.
So what has changed? Actually, a lot!
Factors contributing to 21st Century weight gain:
- Microplastics, pharmaceuticals and other environmental toxins contaminating our food, air and water. Research shows a significant relationship between environmental toxins and hormonal shifts that drive obesity.
- Advancements in technology that promote sedentary lifestyles. People are spending hours each day interacting with screens, at the cost of reduced physical activity.
- Increased consumption of aggressively marketed processed and fast foods laden with sugar, seed oils and chemicals that promote obesity.
- Sugary beverages like soda, coffee beverages, sweet tea, sports and energy drinks, and milkshakes that have taken the place of simple water, tea and coffee.
- Larger serving sizes that cause us to eat more. An adult meal at a popular hamburger restaurant in the 1960s was the size of a child’s meal today. When you say “supersize it,” you may be supersizing yourself.
- Urban centers designed for cars and trucks, making roads risky for other modes of transport like walking and biking.
- Chronic stress and sleep deprivation that disrupt hunger hormones like ghrelin and leptin, and promote emotional eating, leading to cortisol-driven fat storage.
- Certain medications like antidepressants, corticosteroids, and antipsychotics have been shown to cause weight gain.
- Disruptions to the gut microbiome, caused by chemicals like BPA in plastics, insecticides like glyphosate in wheat and processed foods, and antibiotic medications that destroy essential gut bacteria.
- Economic changes, from labor-driven to consumer-driven economies, making people more sedentary while encouraging greater consumption of processed foods.
Metabolism and Weight Management
Your basal metabolic rate (BMR) is the minimum amount of energy expended by your body to perform basic life-sustaining functions at rest, such as breathing, cellular activity, and circulation. BMR is influenced by factors like age, sex, body size, and lean muscle mass. Younger, larger males with a higher lean mass typically have a higher resting BMR. Essentially, the lower your BMR, the harder it is to manage your body weight.
Your daily metabolic rate is determined by your BMR + your daily activity level + the thermic effect of food + adaptive thermogenesis – a decrease in energy expenditure that occurs after weight loss. Both your basal and your daily metabolic rate can be easily manipulated by lifestyle factors.
Mitochondria are organelles in every cell responsible for converting fat and glucose into ATP, the energy molecule. The number and size of cellular mitochondria are determined by metabolic demand. A physically active person who places a high demand on the body’s systems typically has more and larger cellular mitochondria, to meet the body’s energy needs.
Mitochondria are the primary regulators of metabolic rate and daily energy expenditure, and they in turn depend on ample amounts of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme found in all living cells. Your body makes NAD+ from dietary sources, but NAD+ production peaks in your 20s and then gradually declines with age.
NAD+ deficiency impacts basal metabolism by:
- Impairing mitochondrial energy production.
- Inhibiting repair of DNA and damaged cells.
- Impeding sirtuin activity that governs thermogenesis and metabolic rate.
- Triggering an adaptive response that favors glycolysis (sugar) over fat metabolism.
Supplementing with NAD+ promotes a higher basal metabolism, setting the conditions needed for fat metabolism, enhanced exercise performance, and improved hormonal balance — especially when combined with lifestyle modifications.
NAD+ promotes healthy body weight by:
- Increasing mitochondrial ATP production, meaning more energy burned at rest.
- Enhancing glucose and insulin signaling, meaning more sustained energy and less fat storage.
- Reducing inflammatory cytokines that create barriers to weight loss.
- Enhancing DNA and cellular repair, for greater metabolic stability.
- Balancing neurotransmitters and appetite, for less emotional eating and reduced food cravings.
Lifestyle Factors are Key to Weight Management
NAD+ can help boost your metabolism, but it does not provide a stand-alone solution. When incorporated as a part of a lifestyle-based weight management strategy, NAD+ IV therapy can help support the metabolic processes that burn excess energy at the mitochondrial level.
Adopt these key lifestyle behaviors to boost your metabolism and manage your weight:
- Eliminate sugar and simple carbohydrates from your diet. This may be the single most important change you can make to shift your body from burning sugar to burning fat. Sugar, flour, rice, and potatoes are all simple carbohydrates that promote fat storage. Processed foods and beverages are typically sky-high in sugars and simple carbs, so avoid them at all cost.
- Drink more water. Water makes up to 75% of your body mass, and is essential for brain and vital organ function, muscle action, energy production, and nerve transmission. Water is a key component of the extra-cellular matrix that provides tissue structure and regulates cell behavior. Opt for spring water, and avoid tap water.
Cut Sugar & Simple Carbs
Reducing sugar and simple carbs helps shift your body from burning glucose to burning fat, lowering insulin spikes and fat storage.
Hydrate With Clean Water
Clean water supports cellular function, energy production, and tissue repair. Proper hydration helps stabilize metabolism and improve overall vitality.
- Get daily exercise. Begin with a simple walking program of 30 minutes daily, and gradually add resistance training and stretching to promote mitochondrial activity and elevate basal metabolic rate.
- Optimize sleep by going to bed at the same time each day, avoiding screens before bed, and sleeping in a cool, dark room. Sleep deprivation is a key driver of weight gain.
Daily Movement
Regular movement boosts mitochondrial activity, supports fat burning, and elevates your resting metabolic rate.
Build Strength & Flexibility
Gentle resistance training and stretching improve muscle function, metabolism, and mitochondrial efficiency.
- Switch to a ketogenic or Mediterranean-style diet, with plenty of fresh fruits and vegetables, and wild-caught or pasture-raised fish, poultry and meats.
- Adopt time-restricted eating – aka intermittent fasting – an evidenced-based strategy that limits daily food consumption to a specific window of time, typically ranging from 4-12 hours.
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Ketogenic / Mediterranean Diet
A nutrient-dense diet rich in vegetables, healthy fats, and quality proteins supports metabolic health and stable energy.
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Time-Restricted Eating
Limiting meals to a daily eating window enhances insulin sensitivity, supports fat metabolism, and stabilizes appetite.
What to Expect with NAD+ Therapy
| Timeline |
Cellular Shift |
You May Notice |
| Day 1–3 |
Rapid NAD+ elevation and ATP support |
Mental clarity, reduced fatigue |
| Week 1–2 |
Improved insulin efficiency + glucose balance |
Fewer crashes, more stable appetite |
| Week 3–6 |
Mitochondria stronger and more active |
Better workouts, fat mobilization |
| Week 8+ |
Inflammation decreases, metabolic pathways normalize |
Waistline and lab markers improve |
Get Weight Loss Support at InVita Wellness in SoHo NYC
At InVita Wellness in SoHo NYC, we’ve spent over a decade optimizing NAD+ protocols for real-world metabolism and weight control benefits:
1.NAD+ IV infusions
- High-dose, rapid clinical delivery
- Completely personalized drip speed and dosing
2.NAD+ Injections
- 1–2x weekly for ongoing mitochondrial and metabolic support
- Fast and effective with no downtime
3.NAD+ Transdermal Patches (NEW)
- Slow-release, travel-friendly NAD+ delivery
- Ideal between IVs or for clients not ready for injections
- Keeps NAD+ levels steady throughout the day
✅ Optimization Add-Ons
- CoQ10, Lipo-B, Alpha-Lipoic Acid, B-Complex, Glutathione, Vitamin D
- Hyperbaric Oxygen Therapy for improved energy and metabolic repair
- Peptide protocols for weight, muscle, or recovery synergy
✅ Concierge-level dosing and guidance for clients who travel or want long-term support
To reset your metabolism and jump-start your weight loss journey, contact InVita Wellness today!
What Our Clients Say About NAD+ and Weight Loss
1. 42-year-old client, post-career burnout
“I hit a wall in my 40s, and NAD+ got my metabolism humming again.”
2. 52-year-old business professional
“After years of dieting and working out, I hit a plateau. NAD+ flipped a switch.”
*Disclaimer: NAD+ therapy at InVita Wellness is provided for general wellness, vitality, and longevity support. It is not a treatment for obesity or a substitute for medical weight-loss management unless specifically directed by a licensed provider. All services are supervised by medical professionals, and products are sourced from US-licensed pharmacies.
To jump-start your weight loss journey
contact InVita Wellness today
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456 Broadway 2 Floor, New York, NY 10013, USA
*Disclaimer: NAD+ therapy at InVita Wellness is offered for general wellness and longevity support. It is not intended to diagnose, treat, or cure medical conditions. All services are provided under medical supervision with products sourced from licensed US pharmacies. Always consult your healthcare provider to determine if NAD+ therapy is right for you.
Resources
Ćurčić, Marijana, et al. “Environmental pollutants and the obesity: Proven causalities and open questions.” Archives of Pharmacy 74.Notebook 3 (2024): 426-435.
[PDF] ceon.rs
Hua, Zixin, et al. “Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes.” Diabetes, Obesity and Metabolism 27.2 (2025): 920-932.
https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.16092
Van Hul, Matthias, and Patrice D. Cani. “The gut microbiota in obesity and weight management: microbes as friends or foe?.” Nature Reviews Endocrinology 19.5 (2023): 258-271.
The gut microbiota in obesity and weight management: microbes as friends or foe?
