Chronic systemic inflammation is a menacing precursor to joint osteoarthritis and metabolic disorders that diminishes your quality of life. Inflammation is driven by a broad range of lifestyle and environmental factors over the course of several years. While inflammation can affect people of all ages, it is a common denominator among older adults, marked by the degradation of DNA and mitochondrial dysfunction.
Learn about the mechanisms of chronic inflammation and aging, and how an intravenous nutrient cocktail of NAD+ and curcumin can help slow the aging process while banishing systemic inflammation.
Chronic Inflammation: The Silent Killer
Low-grade chronic systemic inflammation is often referred to as a silent killer because of its gradual onset. Most people are not aware of the problem until it begins to manifest as a serious health threat. According to one report, chronic inflammation is the underlying cause of 3 out of 5 deaths worldwide.
Conditions associated with chronic inflammation include:
- Hypertension
- Heart disease
- Stroke
- Chronic respiratory diseases
- 25% of Cancers
- Obesity
- Diabetes
- Mitochondrial dysfunction
Sadly, most people only learn about chronic inflammation after its symptoms are well-entrenched.
Medical doctors are quick to prescribe prescription drugs with harmful side effects to manage symptoms, without addressing the core causes of systemic inflammation. Before long, patients find themselves dependent on multiple medications while their health continues to deteriorate.
Lifestyle Factors that Promote Inflammation
Taking proactive measures early on to safeguard your health can ward off inflammation and dramatically enhance your longevity and quality of life. Lifestyle factors are the main drivers of chronic inflammation, their effects accumulating over time and affecting cellular health.
Pro-inflammatory lifestyle factors include:
- Chronic stress
- Poor sleep habits
- Poor nutrition
- Sedentary lifestyle
- Obesity
- Chronic dehydration
- Excess alcohol consumption
- Exposure to environmental toxins
The good news is that adopting healthy lifestyle behaviors can reduce and reverse chronic inflammation and the health conditions it causes. You can start to make changes right away that will have an immediate impact on inflammation control.
Nutrition plays a key role in inflammation and metabolic health. Eliminating sugars and chemical-laden processed foods and replacing them with fresh produce and natural proteins is a giant step toward inflammation control and disease prevention. Anti-inflammatory supplements like curcumin can help reverse inflammation and its harmful side effects.
Regular physical activity goes hand-in-hand with nutrition when it comes to reversing inflammation. Daily walking alone can be transformative, helping to enhance cellular health and promoting better sleep. However, physical activity relies on the cells’ mitochondria for energy production, so mitochondrial health should be prioritized.
Inflammation and Mitochondrial Health
One of the most threatening consequences of chronic inflammation is its effect on mitochondrial function. Mitochondria are the “energy factories” found within every cell in your body, where fats and carbohydrates are converted to ATP. Degradation of the mitochondria has been identified as a key factor in the aging process, and most aging-related diseases, including neurodegenerative diseases, involve the mitochondria.
Mitochondrial dysfunction is associated with a broad range of metabolic and neurological disorders:
- Respiratory failure
- Liver failure
- Kidney failure
- Diabetes
- Pancreatitis
- Intestinal and digestive disorders
- Bone issues
- Eye problems
- Hearing loss
- Exercise intolerance
- Peripheral neuropathy
- Multiple other health issues
Mitochondrial health is largely dependent on Nicotinamide Adenine Dinucleotide (NAD), a coenzyme found in every cell of your body. Your body makes NAD from foods containing niacin (Vitamin B3). However, NAD levels naturally decline as you age. Eating a diet rich in B-vitamins can help, but most modern diets – especially vegan and vegetarian diets – are B-vitamin deficient.
Supplementing with NAD and its precursors can help boost NAD production. High-dose intravenous nutrient NAD infusion therapy has been shown to positively impact NAD levels in cellular mitochondria
Inflammation and DNA Damage
In addition to contributing to a host of metabolic and neurological disorders, inflammation has been shown to damage DNA. DNA damage is thought to affect multiple aspects of aging, involving a wide variety of features at the molecular, cellular and physiological levels.
DNA damage is thought to influence multiple facets of aging:
- Mitochondrial dysfunction
- Metabolic disorders
- Stem cell dysfunction
- Proteostasis – the regulation of proteins within cells
- Nutrient sensing
- Adaptation to stress
- Epigenetic control – factors that control gene activity without altering the DNA sequence
- Autophagic flux – the natural degradation of cells to remove dysfunctional components, and the recycling of functional components
- Accumulation of damaged cellular components
NAD+ serves as a substrate for multiple regulatory aspects of DNA damage repair. It helps to maintain DNA integrity, slowing and possibly reversing multiple characteristics of aging. A decline in NAD+ synthesis is strongly linked to DNA damage and accelerated aging. Supplementation of NAD+ and its precursors, along with modification of destructive lifestyle factors, can tap the brakes on aging and set you on a path toward better health.
The Synergistic Effects of NAD+ and Curcumin Intravenous Nutrient Infusion
Medical doctors use a variety of prescription and over-the-counter medications to treat systemic inflammation. However, many have dangerous side effects that ultimately harm your health. Moreover, drugs only treat the symptoms of inflammation, ignoring the factors that cause it.
Popular anti-inflammatory drugs include:
- NSAIDs – non-steroidal anti-inflammatory drugs like ibuprofen (Advil) and naproxen (Aleve). While these drugs can temporarily reduce pain and inflammation, they can have severe long-term side effects, including stomach ulcers, bleeding, heart attacks and liver damage.
- Corticosteroids like prednisone, taken orally or by injection. Steroids work by suppressing the immune system’s ability to cause inflammation. However, since inflammation is a natural immune response to pathogens, use of steroids can lower your resistance to a number of threats while ignoring the underlying causes of inflammation. Long-term corticosteroid use is linked to significant side effects, including weight gain, osteoporosis and mood disorders.
- Immunosuppressants, chemical compounds that suppress the immune response. Like steroids, immunosuppressants seek to suppress inflammation at the expense of lowered immune defenses to fight infections.
- Biologics – substances derived from living cells that are engineered to target specific cells and proteins involved in inflammation. Biologics can be more potent than other immunosuppressors, and patients must be closely monitored due to an increased risk of infections
Unlike dangerous drugs that threaten your health, NAD+ and curcumin are natural nutrients that combat inflammation and its negative effects on health and aging. Because NAD+ and curcumin are nutrients and not drugs, you don’t need a medical prescription, and there are no negative side effects.
The synergistic effects of NAD+ and curcumin intravenous nutrient infusions can positively affect your health by healing damaged mitochondria and repairing DNA while banishing chronic systemic inflammation and its harmful effects on your health.
Get Safe and Effective NAD+ and Curcumin Intravenous Nutrient Infusion Therapy in NYC
Aging is a natural part of the cycle of life, but how well you age can dramatically affect your quality of life. Combating aging is not just about living longer – it’s about living better. Intravenous nutrient infusions of NAD+ and curcumin can help to fight systemic inflammation, slow the aging process, and give you more energy to enjoy the things you love.
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InVita Wellness offers top-quality intravenous nutrient therapy to meet your nutritional needs and enhance your health. Contact us today, and take proactive steps to stop inflammation and aging in their tracks.
Resources
Haas, Richard H. “Mitochondrial dysfunction in aging and diseases of aging.” Biology 8.2 (2019): 48.
Kawanishi, Shosuke, et al. “Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis.” International journal of molecular sciences 18.8 (2017): 1808.
Margină, Denisa, et al. “Chronic inflammation in the context of everyday life: dietary changes as mitigating factors.” International journal of environmental research and public health 17.11 (2020): 4135.
Pahwa, Roma, et al. “Chronic inflammation.” (2018).
Russell, Oliver M., et al. “Mitochondrial diseases: hope for the future.” Cell 181.1 (2020): 168-188.
