Tirzepatide: A Promising New Solution for Diabetes and Obesity

Home » Tirzepatide: A Promising New Solution for Diabetes and Obesity

The growing trend of obesity in adults and children has become a world-wide health threat. According to the most recent statistics (2017-2018) from the National Health and Nutrition Examination Survey (NHANES):

1 in 3 adults is overweight

1 in 6 children age 2-19 is overweight

2 in 5 adults are clinically obese

1 in 5 children age 2-19 is obese

While post-pandemic statistics on obesity are not yet available, we can expect to see greater percentages of the population diagnosed as overweight or obese.

To combat the growing trend of obesity and its associated metabolic comorbidities like hypertension and diabetes, researchers are looking for effective solutions to help people lose weight and reduce health risks that lead to premature death.
Weekly tirzepatide injections have recently been approved by the FDA to treat diabetic and obese patients, helping them to lose weight and achieve a better quality of life.

What is Tirzepatide?

Tirzepatide — also marketed under the brand names Mounjaro and Zepbound — is a fairly new antidiabetic medication used for the treatment of type 2 diabetes and weight loss.. Administered weekly by subcutaneous injection, tirzepatide works by suppressing appetite and reducing total food intake.
The FDA has approved tirzepatide for chronic weight management in clinically obese adults, and in overweight adults with at least one metabolic condition such as high blood pressure, type 2 diabetes, dyslipidemia or heart disease.

Tirzepatide is meant to be used as an adjunct to diet and exercise

Tirzepatide

DIET

exercise

Tirzepatide Mechanisms of Action

Tirzepatide works by imitating GLP-1 and GIP — digestive hormones that the intestine secretes after a meal. The hormones trigger insulin secretion, helping your body to manage blood sugar levels. The drug also slows down the time it takes for food to leave the stomach, and signals the brain that you are full and satiated.

Tirzepatide helps you lose weight by:

Suppressing
appetite

Slowing the digestive
process

Making you
feel satiated

Triggering insulin
secretion

Semaglutide vs Tirzepatide

Tirzepatide and semaglutide are both prescribed to manage type 2 diabetes and for weight loss.
They both help you lose weight by making you feel less hungry.
Like tirzepatide, semaglutide mimics the GLP-1 hormone. However, unlike tirzepatide, semaglutide does not mimic the GIP hormone that triggers insulin secretion and creates a feeling of fullness.
Semaglutide has the advantage of being offered as an oral tablet or by injection, while Tirzepatide is only available by injection.

While some studies show promising results, it is too early to know if tirzepatide outperforms semaglutide for weight loss. Current available research has only studied and reported weight loss in people with type 2 diabetes, and no studies exist that match the two medications dose per dose.

Clinical Trials for Tirzepatide Weight Loss

Since the drug’s approval, multiple studies have been published regarding the effectiveness of tirzepatide for weight loss.

One 2024 study set out to see if obese subjects who had lost weight on tirzepatide would maintain their results if taken off the drug. Study participants were 670 overweight or obese adults who were not diabetic. They experienced a mean weight loss of 21% after 36 weeks of treatment with a maximum dose of tirzepatide. At the 36-week marker, a control group was switched to placebo, and the study continued for a total of 52 weeks. The placebo group regained 14% of their weight in that time, while the study group lost an additional 5% of body weight. The study concluded that withdrawal from tirzepatide led to substantial weight regain, while those who continued treatment were able to maintain their results and lose additional weight.
One 2024 study set out to see if obese subjects who had lost weight on tirzepatide would maintain their results if taken off the drug. Study participants were 670 overweight or obese adults who were not diabetic. They experienced a mean weight loss of 21% after 36 weeks of treatment with a maximum dose of tirzepatide. At the 36-week marker, a control group was switched to placebo, and the study continued for a total of 52 weeks. The placebo group regained 14% of their weight in that time, while the study group lost an additional 5% of body weight. The study concluded that withdrawal from tirzepatide led to substantial weight regain, while those who continued treatment were able to maintain their results and lose additional weight.

Tirzepatide Potential Side Effects

Moderate side effects of tirzepatide include:

Constipation or diarrhea
Upset stomach, nausea and vomiting
Headaches
Abdominal pain
Fatigue
Low blood sugar (hypoglycemia)

More severe side effects of tirzepatide include:

Vision changes
Pancreatitis
Kidney failure
Gallbladder issues
Allergic reactions
Risk of thyroid C-cell tumors

Get Tirzepatide for Weight Loss in NYC

If you have type 2 diabetes and/or are struggling to lose weight for better health, tirzepatide may be the right solution for you. Invita Wellness is pleased to be among the first clinics that offer subcutaneous injections of tirzepatide for weight loss in NYC. Contact Invita Wellness today, and see if you qualify as a candidate for tirzepatide treatment.

Resources

Abbasi, Jennifer. “FDA green-lights tirzepatide, marketed as Zepbound, for chronic weight management.” JAMA (2023).

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